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1.
Chinese Journal of Zoology ; 57(6):951-962, 2022.
Article in Chinese | CAB Abstracts | ID: covidwho-20244972

ABSTRACT

Many zoonotic diseases are found in wild animals and present a serious risk to human health, in particularly the virus carried by birds flying freely around the world is hard to control. There are three main bird migration routes which cover the most areas of China. It is important to investigate and fully understand the types of avian transmitted diseases in key areas on the bird migration routines and its impacts on both birds and human health. However, no literature is available in how about the risk of virus carried by migrating birds, and how to predict and reduce this risk of virus spreading to human being so far. In this paper, we first reviewed the main pathogen types carried by birds, including coronaviruses, influenza viruses, parasites, Newcastle disease virus (NDV), etc., and then discussed the spread risk of avian viruses to human being and animals in key areas of biosafety prevention. We also analyzed and discussed the risk of cross-spread of diseases among different bird species in nature reserves located on bird migration routes which provide sufficient food sources for migratory birds and attract numerous birds. Diseases transmitted by wild birds pose a serious threat to poultry farms, where high density of poultry may become avian influenza virus (AIV) reservoirs, cause a risk of avian influenza outbreaks. Airports are mostly built in suburban areas or remote areas with good ecological environment. There are important transit places for bird migration and densely populated areas, which have serious risk of disease transmission. Finally, this paper puts forward the following prevention suggestions from three aspects. First, establish and improve the monitoring and prediction mechanism of migratory birds, and use laser technology to prevent contact between wild birds and poultry. Second, examine and identify virus types carried by birds in their habitats and carry out vaccination. Third, protect the ecological environment of bird habitat, and keep wild birds in their natural habitat, so as to reduce the contact between wild birds and human and poultry, and thus reduce the risk of virus transmission.

2.
Mitteilungen der Osterreichischen Geographischen Gesellschaft ; 164:9-70, 2022.
Article in German | Scopus | ID: covidwho-20244730

ABSTRACT

The COVID-19 pandemic and the policy measures imposed to contain the virus affected people's health and lifestyles. Based on data available to the Federal Agency "Statistics Austria”, this paper asks about the impact of the pandemic years 2020 and 2021 (and partly beyond) on the Austrian demographics and population. It shows that mortality increased significantly during this period but varied by waves of infection also with the introduction of different policy measures (e.g., lockdowns). There are also changes in the number of births over the course of the pandemic, which can be interpreted through insecurities related to lockdowns and vaccinations. People who wanted to marry or get divorced during the pandemic years were confronted with closed offices and restrictions on holding celebrations, which is why there were significantly fewer marriages and divorces. International migration dropped significantly, especially in the spring of 2020, when European and global mobility was severely restricted, with differences between people of different nationalities. This was also reflected in the number of asylum applications filed in Austria. Migrations within Austria were strongly reduced during the first lockdown in 2020, all further lockdowns had less influence on them. However, in 2020 and 2021 there were several phases in which more people moved from urban to rural areas than before the pandemic. The number of registered secondary residences – which took on new relevance in the context of mobility restrictions and the use of home offices – also changed: overall, their number increased during the pandemic, but in many municipalities, deregistrations of seasonal workers were also noticeable. © 2022 Austrian Geographical Society. All rights reserved.

3.
Cuestiones Politicas ; 41(76):136-161, 2023.
Article in English | Web of Science | ID: covidwho-20243846

ABSTRACT

Cuestiones Politicas IEPDP-Facultad CdeidJutarcu Enitrte Hutamaasociay, laiidttrmes;froondnccun, iltueso locnavsu loslsccuas UBSTA Re Bib gra Po Peir nes OIRALITH Using an interpretative methodology, the article examines approaches to the regulation of migrationE dp rocesses in the light of the increasing flow of immigrants to the European Union EU. Maria In this context, two main directions of regulation of migration processes are considered: legal regulation and integration measures. It can be concluded that the international legal regulation of migration processes in the EU is based on adopted and ratified declarations, Reittaesv dtadeilu conventions, covenants and protocols, which form a general international DrHter legal basis for the regulation and management of migration processes at the hiloiiromc interstate level. Accordingly, the analysis of migration legislation and state border legislation allows distinguishing three types of documents according to their content, which are related to the fight against irregular migration: a) regulatory legal acts determine the model of legal entry and stay of a migrant on the territory of the country;b) law enforcement rules establish responsibilities and regulate the application of other coercive measures in case of violation of migration rules, and;c) documents of organizational content determine the competence of the authorities involved in the process of combating illegal immigration. de C a u E a u v i ALITH e M i th H loic

4.
Journal of Rural Development ; 41(2):198-209, 2023.
Article in English | CAB Abstracts | ID: covidwho-20243469

ABSTRACT

In March 2020, a large number of people moved from cities to their homes in rural areas, and a few months later, many returned to cities. These journeys were undertaken not only during the COVID-19 pandemic against the advisory of governments and public health experts, but the circumstances of travel were also under extreme hardship. How may we understand this intense response by people? By drawing on the migration theory and the roles of social ties or social organisation, we can better explain peoples' reactions during this pandemic. Notably, we find non-material values, such as the dignity of labour or responsibilities to family, are significant to decision -making, and there is a desire not to compromise on these values. Further, our analyses find that the distinction between pre-disaster and post-disaster situations may not be helpful.

5.
Handbook of Health and Well-Being: Challenges, Strategies and Future Trends ; : 397-415, 2022.
Article in English | Scopus | ID: covidwho-20243451

ABSTRACT

Migration is a pronounced trend that has massively contributed to the industrialization process across the world. This vast labor pool that floated from a less-developed place to a more-developed place for better livelihood is our population of interest. This chapter examines the health and well-being of the floating laborer community of India, who are involved in some form of development projects both within the nation. It identifies the role of socioeconomic and political correlates in setting the context of migration in the country. Aspects of health including both physical and mental health with special emphasis on occupational hazards are explored. The general status of older adults, women, and children is studied to further expand on how needs such as housing, schooling, ration, and pediatric, maternity and geriatric healthcare needs are met in their migrated land. Benefits and risk factors of migrants, as well as topics such as inequity, discrimination, resources availability, and unemployment are analyzed. A dedicated session is set that observes the impact of COVID-19 pandemic on the overall health and well-being of laborer community and investigates the exploitation they are subjected to from their host companies/agencies. The chapter is exclusively tailored to learn about the overall health and wellbeing of the migrant community, and to identify the key factors involved in determining their well-being. The discussion concludes with a few recommendations that involve the collaborative effort of all stakeholders involved in migration. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Taylor and Francis Pte Ltd. 2022.

6.
Population Space and Place ; 2023.
Article in English | Web of Science | ID: covidwho-20243038

ABSTRACT

COVID-19 has brought a combination of health, socioeconomic and protection challenges to migrants everywhere, and a common view is that these effects have been harshest for those already in vulnerable situations before the pandemic. However, the lived experiences of Filipino irregular migrant domestic workers (IMDWs) in the Netherlands point to a range of impacts instead of a homogenous one. Drawing on interviews and participant observations, we analyse three specific pandemic consequences: income and financial remittance volatility, dual country or transnational precarity and physical and migration status immobility. We then analyse the resilience strategies deployed by IMDWs to navigate through such impacts. While our focus is on the microlevel, we also highlight the vital importance of the responses by the community on the mesolevel, and the government on the macrolevel. Following this relational approach, we put forward a conceptualisation of individual resilience as the capacity to navigate the negative impacts of a shock or crisis to maintain, adapt, or transform valued functionings. We argue that IMDWs cultivate resilience despite their precarious legal status;however, the effectiveness of strategies is contingent on personal circumstances as well as the sociopolitical context wherein they are deployed. The paper contributes to the literature by providing a more nuanced picture of the impacts of and responses to COVID-19 in relation to migrants with irregular status. The articulation of resilience in terms of valued functionings also paves the way for the advancement of the still nascent research agenda on migration and human development.

7.
International Journal of Gastrointestinal Intervention ; 12(2):103-104, 2023.
Article in English | EMBASE | ID: covidwho-20242860

ABSTRACT

We retrospectively report a case of rapid exchange of a percutaneous radiologic gastrostomy tube (balloon-occluded type catheter) via off-label use of a pigtail catheter for nutrition supply during a very early episode of coronavirus disease 2019 (COVID-19) in an outpatient clinic. This case demonstrates that minimally invasive percutaneous procedures might be provided safely and effectively under appropriate precautions for preventing COVID-19 transmission during the pandemic.Copyright © 2023, Society of Gastrointestinal Intervention.

8.
Value in Health ; 26(6 Supplement):S183, 2023.
Article in English | EMBASE | ID: covidwho-20241923

ABSTRACT

Objectives: To provide an update overview on the current status of healthcare systems in the Maghreb region (Algeria, Morocco, and Tunisia) and to emphasize the progress made in the midst of the challenges facing these countries. Method(s): A descriptive comparative approach of healthcare systems in the three countries, based on data from sources with an established methodology, including descriptive healthcare data from the WHO database. Result(s): The population of the Maghreb will increase from 102 million to 132 million by 2050. The current population is mostly centered in Algeria and Morocco, accounting for 77%. Annual healthcare expenditure per capita is 447.9$, 776.8$ and 854.6$ in Morocco, Tunisia and Algeria, respectively. The average infant mortality rate per 1000 live improved to 10.9 in Tunisia, 16.8 in Morocco and 18.9 in Algeria. Maternal mortality rates have dropped to 43 and 48.5/100 000 births in Tunisia and Algeria, respectively while remaining relatively high in Morocco: 72.6. Number of hospital beds/1000 inhabitants is only 1.1 in Morocco, 1.9 and 2.9 in Algeria and Tunisia, respectively. The number of physicians/1000 people was 0.73 in Morocco, 1.3 in Tunisia and 1.72 in Algeria. This remains considerably low compared to the 3.9/1000 in Europe. The Maghreb countries are currently facing an exodus of physicians, mainly to France, which represents 7.1% and 10.7% of Tunisians and Moroccans, respectively, and more than 24% for Algerians. The Maghreb countries were very early mobilized (governments, ministries of health, civil society) to fight against COVID-19 and have successfully controlled the pandemic, according to pre-established control strategies and the strongly commitment of health professional. Conclusion(s): Despite the considerable progress made, the Maghreb countries still face major challenges. Physicians migration, rising cost of care and endemic infectious disease outbreaks constitute a huge hurdle on the already overburdened and resilient healthcare systems.Copyright © 2023

9.
Sustainability ; 15(11):8816, 2023.
Article in English | ProQuest Central | ID: covidwho-20241756

ABSTRACT

Until recent decades, labour-intensive subsistence farming was a way of life and livelihood in the hill communities of Uttarakhand, India. However, the nature of agriculture falls far short of the expectations of the main labour force, the rural youth, leading to their mass migration to non-agricultural occupations. The large-scale youth migration has left many hill farming landscapes depopulated and farmlands abandoned. As youth have special stakes in food systems, they must be included in the sustainable transformation of food systems. By doing so, the migration-prone hill region may be transformed into a place where rural youth have more options for work and income. Therefore, the agriculture sector needs to change and develop into a more engaging and youthful workplace. There are opportunities to explore and barriers to be removed. Besides identifying priority research areas on local food systems, in this exploratory research, we investigate opportunities to involve rural young people in the transformation of the food system. We document information by conducting focus group discussion (FGD) meetings in about 100 villages in the Uttarakhand hills, representing all major farming landscapes. This study mainly focuses on improving the production and consumption aspects of local food, which not only benefits the health and wellbeing of local communities but also has many positive economic, social, and environmental effects. In addition, we explore opportunities for reviving mountain agriculture through agri-ecotourism, which is a symbiotic relationship between tourism and agriculture. Making home- or farm stays in agri-ecotourism a subsistence strategy for local youth will contribute to a more prosperous rural economy. Recognising Uttarakhand's rich culture and heritage while exploring the culinary travel opportunities in homestays will provide opportunities to focus more on traditional food systems, exposing various tangible and intangible aspects of the host region's food culture to tourists. The findings of this study will aid in identifying specific policy issues for consideration by planners and policymakers at the local and state levels. Additionally, this exploratory study will assist young, motivated researchers in conducting follow-up, in-depth investigations and producing empirical data in their specialised fields.

10.
African Human Mobility Review ; 8(2):41-74, 2022.
Article in English | Scopus | ID: covidwho-20241607

ABSTRACT

Notwithstanding the wealth of research on migration and subjective wellbeing, the issue of moonlighting and its welfare implication among migrants has not been thoroughly explored in empirical literature. Using rich individual-level panel data from the University of Cape Town's National Income Dynamics Study (NIDS), this study established a number of interesting findings: (a) there is moonlighting among international migrants;(b) hours spent on the primary job and financial motive, among other socio-demographic factors are key predictors of moonlighting;(c) international migrants are more likely to have more than one job, very often to meet contingencies, but mostly to help smoothen consumption over the life cycle;and (d) individuals who spend more hours on their primary job are less likely to moonlight. Regarding wellbeing and happiness, it is evident that moonlighting and hours spent on primary jobs negatively influence self-reported wellbeing and happiness. Given the ravaging effects of the COVID-19 pandemic, and the potential change in the dynamics of the post-pandemic migration trajectory, job search strategies and economic activities, gaining a deeper appreciation of moonlighting and its implication on the wellbeing of migrants is essential to national and international policy rethinking in order to achieve a triple win for the migrant, the host and origin countries. © 2022, University of the Western Cape. All rights reserved.

11.
The International Migration Review ; 57(2):505-520, 2023.
Article in English | ProQuest Central | ID: covidwho-20241317

ABSTRACT

Every government in the world introduced restrictions to human mobility – that is, the movement of persons across and within state borders – in response to the COVID-19 pandemic. Such restrictions thus constituted a global phenomenon, but they were by no means globally uniform;rather, they varied significantly between and within states, as well as over time. This research note presents different data sources for studying the drivers and outcomes of mobility restrictions, highlighting specific ways in which the data can be used. We begin by surveying seven new databases capturing various aspects of the regulation of human movement during the COVID-19 pandemic. Drawing inspiration from research on previous pandemics, we then outline five possible research avenues prompted by these data. We suggest that explaining the causes and consequences of such restrictions, as well as the differences between them, can significantly advance research on the governance of mobility, migration, and citizenship.

12.
Eurasian Geography & Economics ; : 1-29, 2023.
Article in English | Academic Search Complete | ID: covidwho-20240629

ABSTRACT

Changing spatial patterns of migration are closely related to the transformation of economy and society. Most current studies focus either on international migration or on the migration of particular urban regions. Our study evaluates migration trends in the entire national regional system, and thus it contributes to its comprehensive understanding. The study aims to evaluate the relationship of internal migration from economically lagging eastern to more developed western regions of Slovakia on the one hand, and migration between categories of regions according to the hierarchical position of their urban core on the other hand. The study follows the differential urbanization concept and analyses detailed data on individual migrations in Slovakia in 1996–2020. It thus covers the period from the post-socialist transformation to the COVID-19 pandemic. The results show the increasing intensity of east-west and up the urban hierarchy migration. Due to the significant polarization of migration between the eastern and western regional subsystems, we examined separately in both subsystems the migration excluding flows between the subsystems. The results revealed a concentration of population into metropolitan regions in both subsystems, although the intensity of the processes was lower and the onset of trends delayed in the eastern subsystem. A significant feature of development in the post-socialist period was intensive exurbanation in both subsystems. The study thus points to the importance of subnational and regional approaches to migration research, and reveals trends that can contribute to the explanation of migration development even in countries where such detailed migration statistics are not available. [ FROM AUTHOR] Copyright of Eurasian Geography & Economics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

13.
Professional Geographer ; 75(3):415-429, 2023.
Article in English | Academic Search Complete | ID: covidwho-20240450

ABSTRACT

As the COVID-19 pandemic swept across the United States, the media began reporting stories of people leaving cities for rural destinations, setting off frenzied real estate activity in receiving communities. This article builds a case study of New England using nonconventional data collected from mobile devices as a proxy for population to explore the temporal and spatial patterns of movement down the urban hierarchy since the onset of the COVID-19 pandemic. Two research questions guide the analysis: (1) How have urban–rural migration systems in New England shifted since the onset of the COVID-19 pandemic? (2) In what ways have real estate markets been affected by these apparent migration shifts? The analysis reveals shifts of population away from metropolitan core areas of the region and into micropolitan and noncore counties. These population shifts were most pronounced in late summer and fall 2020 with loosening travel restrictions. By the end of 2020, migration systems in New England once more resembled prepandemic patterns. Further, these places down the urban hierarchy consistently showed more substantial increases in real estate activity as reflected in rising prices, reduced inventories, and increased sales volume. These real estate dynamics suggest urban to rural migration during the COVID-19 pandemic might be initiating new waves of rural gentrification. (English) [ FROM AUTHOR] A medida que la pandemia del COVID-19 afectó por todo lado los Estados Unidos, los medios empezaron a informar sobre historias de gente que dejaban atrás las ciudades por destinos rurales, desencadenando una frenética actividad inmobiliaria en las comunidades receptoras. Este artículo construye un estudio de caso de Nueva Inglaterra, usando datos no convencionales recogidos de dispositivos móviles, como un proxy por la población para explorar los patrones temporales y espaciales del movimiento descendente desde la jerarquía urbana a partir de la aparición de la pandemia del COVID-19. El análisis se guía por dos preguntas de investigación: (1) ¿Cómo han cambiado los sistemas de migración ciudad–campo en Nueva Inglaterra desde el comienzo de la pandemia del COVID-19? (2) ¿De qué manera se han visto afectados los mercados inmobiliarios por estos cambios aparentes de migración? El análisis revela desplazamientos de población fuera de las áreas del núcleo metropolitano de la región hacia condados micropolitanos y no nucleados. (Spanish) [ FROM AUTHOR] 随着COVID-19流行病席卷美国, 媒体开始报道人们离开城市前往农村、在农村引发疯狂的房地产活动。本文构建了美国新英格兰地区(New England)案例, 使用来自移动设备的非常规数据替代人口数据, 探索了COVID-19流行病发生以来由城市迁移到农村的时空模式。研究分析了两个问题:(1)自COVID-19发生以来, 新英格兰地区的城乡迁移体系如何变化?(2)这些显著的迁移变化, 对房地产市场产生了哪些影响?分析表明, 人口从新英格兰大都市核心区域迁移到小城镇和非核心县。随着旅行限制的放松, 人口迁移在2020年夏末和秋季最为显著。到2020年底, 新英格兰地区的迁移体系, 再次呈现出类似于COVID-19之前的模式。处于城市等级体系底层的地区, 房地产活动持续大幅增长, 这反映在价格上涨、库存减少和销售量增加。房地产变化表明, 在COVID-19流行病期间, 城市到农村迁移可能会引发新一轮的农村中产阶级化。 (Chinese) [ FROM AUTHOR] Copyright of Professional Geographer is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

14.
Anthropology Southern Africa (2332-3256) ; 46(1):21-33, 2023.
Article in English | Academic Search Complete | ID: covidwho-20240218

ABSTRACT

This ethnographic study highlights the impact of Covid-19 border closures on the migration patterns of Zimbabwean cross-border migrants. Data in this study were collected using qualitative techniques, one-on-one telephonic interviews and social media platforms from 20 participants over a period of five months. The data were analysed using the theoretical framework of conviviality. Our findings indicate that Zimbabwean cross-border migrants managed to cross into South Africa and back despite restrictions, which suggests that border closures had a limited impact on migration. By drawing on the narratives of Zimbabwean cross-border migrants, we illustrate how migrants, goods and remittances managed to move and how social networks such as hushamwari [friendship] played a significant role in facilitating illegal border jumping, revealing the permeability and porousness of state borders to many diverse types of incursions. The closure of national borders during lockdowns highlights the differences between migrants and border jumpers, the latter of which chose to smuggle goods in novel ways, even though they possess legal documentation and economic status. (English) [ FROM AUTHOR] Este estudo etnográfico destaca o impacto do fechamento de fronteiras durante a pandemia de Covid-19 nos padrões de migração dos migrantes transfronteiriços do Zimbábue. Os dados deste estudo foram coletados usando técnicas qualitativas, entrevistas telefônicas individuais e plataformas de mídia social com 20 participantes durante um período de cinco meses. Os dados foram analisados a partir do referencial teórico da convivialidade. Nossas descobertas indicam que os migrantes transfronteiriços do Zimbábue conseguiram entrar e voltar da África do Sul apesar das restrições, o que sugere que o fechamento das fronteiras teve um impacto limitado na migração. A partir das narrativas dos migrantes transfronteiriços do Zimbábue, ilustramos como migrantes, bens e remessas conseguiram circular e como as redes sociais como hushamwari [amizade] desempenharam um papel significativo na facilitação do salto ilegal de fronteira, revelando a permeabilidade e a porosidade das fronteiras dos Estados aos mais diversos tipos de incursões. O fechamento das fronteiras nacionais durante o confinamento destaca as diferenças entre migrantes e saltadores de fronteira, tendo estes últimos optado por contrabandear mercadorias de novas maneiras, embora possuam documentação legal e status econômico. (Portuguese) [ FROM AUTHOR] Copyright of Anthropology Southern Africa (2332-3256) is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

15.
Revue Medicale Suisse ; 16(701):1446-1447, 2020.
Article in French | EMBASE | ID: covidwho-20240020
16.
Empiria ; - (58):15-34, 2023.
Article in Spanish | ProQuest Central | ID: covidwho-20239671

ABSTRACT

Qualitative social research on the lives of migrants in Chile involves investigating the social suffering that arises from the "migratory condition" that is produced. The progressive recrudescence of migration policies both at national and international level since the end of the 20th century has further deepened the effects of the COVID 19 pandemic, generating a complex scenario for research in this area for two reasons: the online modality assumed by the interviewing exercise, and the increase of frictions in the relationship between Chileans and migrants. In this text we ask ourselves how to investigate someone who suffers, for which we stop, on the one hand, in the interview as an exercise that should be vigilant of the structural conditions in which it occurs and that can produce symbolic violence, while it should tend to the understanding of the social from the singularity of a life that the interview attends. This implies considering that the ethics of research runs through the very exercise of, in this case, the interview, so that it is not an external constraint to the method, but an integral part of its deployment. Informed consents play a fundamental role in the achievement of the above, however, they often turn out to be standardized protocols that fail to protect or inform the participating subjects, given their technical language and the little reflection on the social relationship they establish, with the result that Informed Consent ends up being installed in the distance between the researcher and the research participant. This is why it is necessary to stop and consider what is understood by ethics, in order to make the interview a fair institution that is built on the recognition of the other as part of the research exercise. Thus, ethics in qualitative social research must be recognized as both situated and, therefore, as reflexive and non-standardized. Thus, we conclude by arguing that in qualitative social research, understanding and ethics are imbricated in a single exercise.

17.
Cytotherapy ; 25(6 Supplement):S72, 2023.
Article in English | EMBASE | ID: covidwho-20239522

ABSTRACT

Background & Aim: The pro-angiogenic, immunoregulatory and anti- inflammatory properties of MSCs are being exploited for the development of cellular therapies, including the treatment of graft versus host disease (GvHD), inflammatory bowel disease and COVID-19. SNBTS have developed a GMP process to bank umbilical cord MSCs (UC-MSCs) whereby we can reliably bank 100 vials of 10 million P2 UC-MSCs per cord. Each of these vials can be extensively expanded and stored for specific applications. The ultimate aim of the bank is for off-the-shelf clinical use, e.g., in GvHD or as an adjuvant therapy in Islet transplantations. Methods, Results & Conclusion(s): During process development, different basal media and supplements were screened for proliferation and MSC marker expression. Cells grown in promising media combinations were then tested for tri-lineage differentiation (identity), their chemokine/cytokine expression and T-cell inhibition (function) assessed. Medium selected for further GMP development and scale up was ultimately determined by all round performance and regulatory compliance. GMP-like UC-MSCs were shown to have immune-modulatory activity in T-cell proliferation assays at 4:1 or 16:1 ratios. Co-culture of UC-MSCs and freshly isolated leukocytes, +/- the immune activating agent LPS, show a dose dependent survival effect on leukocytes. In particular, neutrophils, which are normally very short lived in vitro demonstrated increased viability when co-cultured with UCMSCs. The survival effect was partially reproduced when UC-MSC were replaced with conditioned medium or cell lysate indicating the involvement of soluble factors. This improved neutrophil survival also correlates with results from leukocyte migration studies that demonstrate neutrophils to be the main cell type attracted to MSCs in in vitro and in vivo. Genetic modification of UC-MSC may improve their therapeutic potential. We have tested gene editing by CRISPR/Cas9 technology in primary UC-MSCS. The CXCL8 gene, highly expressed in UC-MSC, was targeted in isolates from several different donors with editing efficiencies of 78-96% observed. This translated to significant knockdown of CXCL8 protein levels in resting cells, however after stimulation levels of CXCL8 were found to be very similar in edited and non-edited UC-MSCs. This observation requires further study, but overall the results show the potential to generate future banks of primary UC-MSCS with genetically enhanced pro-angiogenic, immunoregulatory and/or anti-inflammatory activities.Copyright © 2023 International Society for Cell & Gene Therapy

18.
Journal of Ethnic and Migration Studies ; 2023.
Article in English | Web of Science | ID: covidwho-20238287

ABSTRACT

This paper applies the concept of hierarchised mobility to study return migration in Slovakia in the context of the country's EU accession. The analysis is based on the national Labour Force Survey dataset, covering a decade of labour migration and return between the 2008/2009 financial crisis and the Covid pandemic, concentrating in particular on the short-term labour market outcomes for less skilled return migrants. It is found that even under improved economic conditions, patterns of labour mobility set in the aftermath of the EU's Eastern enlargement continued to persist, together with structural inequalities in the Slovak labour market. Returnees in Slovakia face a markedly higher unemployment rate relative to stayers, and are less likely to be self-employed shortly after their return to Slovakia, compared to stayers or migrants. Returnees were also more exposed to instability in their jobs than migrants and stayers. From this perspective, return migration itself is a reflection of hierarchised mobility, as returnees clearly occupy the least stable jobs, and are the most exposed to instability in their employment. It appears that migration patterns from and to Slovakia are ingrained within the broader functioning of the European labour market.

19.
Medico-Legal Update ; 23(2):1-3, 2023.
Article in English | EMBASE | ID: covidwho-20238225

ABSTRACT

Background: In March 2020, the world health organization declared COVID-19 a world wide pandemic. Countries introduced public health measures to contain and reduce its spread. The effect of mandated societal lockdown to reduce the transmission of corona virus disease 2019 (COVID-19) on road traffic accidents is not known. For this we performed an in-depth analysis singdata of emergency and trauma centre UPUMS, Saifai. As most of the manpower was involved in managing Covid patients directly or indirectly, it was a challenge to manage these mass casualty patients who require intensive care as well as Medicolegal documentation, record keeping, Consent for life saving procedures in absence of Relatives. Material(s) and Method(s): We reviewed data on total 2876 road traffic accident records in UPUMS, Saifai from January 1, 2020 through September 30, 2020. We treated March 20th as the first day of mandated societal lock down and 1st July as the first day of re-opening. Result(s): We have found that the reis increase in road traffic accidents resulting in serious or fatal injuries during lockdown and post-lockdown period. There was increased Medicolegal burden in spite of the decreased medical resources, manpower as most of manpower and resources were being utilized for covid patients. Conclusion(s): Road traffic accidents are a prominent contributor to hospitalization and may negatively impact the existing hospital resources directed towards COVID-19.Copyright © 2023, World Informations Syndicate. All rights reserved.

20.
Iberoamerica (Russian Federation) ; - (1):78-101, 2023.
Article in English | Scopus | ID: covidwho-20238205

ABSTRACT

The paper analyzes the transformation of the US migration policy towards Latin American and Caribbean immigrants and refugees. This policy is treated within the framework of the closeness/security – openness / fairness. Currently, the Mexican-American border has become the epicenter of the migration crisis. During the COVID-19 pandemic, sanitary measures reinforced negative trends in dealing with potential asylum seekers. A new feature of the crisis has become the descent diversity of migrants trying to cross the border barrier, it blurred the usual regional context of the problem and affected the nature of the border states migration policy. The article concludes that on the background of the acute migration crisis, the J.Biden administration's attempts to shift the regulatory measures towards liberalization and greater openness remained ineffective. © 2023, Iberoamerica (Russian Federation). All Rights Reserved.

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